Proteins & Antibodies Sponsors 2015

  • Absolute Antibody

    Absolute Antibody is a CRO offering fully customised services for the sequencing, engineering and manufacture of antibodies. Located across two sites in the UK, Absolute Antibody is a recently established company run by a leadership team with a wealth of experience in the development and manufacture of therapeutic antibodies. We focus on making the production of milligram to gram quantities of antibody quicker and more cost effective for early to mid-stage therapeutic projects through the use of proprietary vectors (pUV™), a high-yielding transient mammalian cell line (ABS293™) and a universal purification platform. For early stage projects we offer a variant screening service for cloning and production of microgram to milligram quantities of as many as 96 antibodies in parallel. For later stage projects we offer rapid manufacture of almost any antibody format, such as IgG, Fab and Fab2, up to gram quantities with high purity and low endotoxin suitable for all in vitro and in vivo uses.

  • Agilent Technologies

    Agilent is a leader in the Pharma, life sciences, diagnostics and applied markets. The company provides laboratories worldwide with instruments, services, consumables, applications and expertise, enabling customers to gain the insights they seek. Agilent has one of the broadest solutions portfolios of any company serving the pharmaceutical industry. Our solutions provide precise answers for every segment of the pharmaceutical industry, from disease research and drug discovery to drug development, manufacturing and quality control. The start To finish solution set means customers can get products to market faster. Customers trust us to help them test the purity of their therapeutics. Agilent also ensures that their instruments and processes conform to the highest compliance regulations.

  • Aldevron

    Aldevron provides custom plasmid DNA manufacturing to support many gene and cell therapy applications. With our experience and scientific expertise, we have developed screening strategies to optimize yield and stability of even the most challenging vector plasmids. We also provide consistency at all levels, with a deliberate pathway from research to clinical requirements.  Visit with our team to learn about our additional services including, mRNA, protein production, gene synthesis and antibody development. Aldevron's mission is to advance science, and we have solutions that are designed for you.

  • Avacta Life Sciences

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    Avacta Life Sciences produces small and robust custom affinity proteins called Affimers. Affimers have been specifically engineered as the high affinity reagent of choice for life science research. They provide an exceptional alternative to antibodies for researchers looking for new custom affinity reagents. The Affimer protein scaffold is a biologically inert, biophysically stable scaffold capable of presenting a range of designed or random binding surfaces defined by peptides inserted at 2 different loops. The result is highly specific, high affinity interactions with a wide range of targets including ones that are inaccessible to antibodies. Affimers are designed to work in the same way as the very best antibodies but with additional advantages: 

    •  Quick to develop, typically 7 weeks
    •  Specificity can be controlled
    •  Small (98 aa, 10 kDa), robust and stable
    •  Consistent batch reproducibility
    •  Easily functionalised
    •  Not limited by the immune system
    •  No use of animals
    • A direct replacement for antibodies – no process or workflow change required

    A typical project will take around 7 weeks and require up to 100 µg of your target; greater than 95% purity is preferred but not essential. Affimers are generated by in vitro screening techniques – your target is subjected to multiple panning rounds of a modern library selection method with or without competition, as required by the target type. We are currently screening multiple display libraries with a diversity of >1010 with a high success rate for protein and small molecule targets. Finally, rigorous quality control is carried out the candidate Affimers are then ranked according to performance and stability, 50 µg* of the top three Affimers will be sent to you for evaluation in your own lab and assay format to allow you to select the best for your application. Once you have made your selection you will be provided with the plasmid and protocols for expression and purification of your preferred candidate and further quantities of any of the Affimers provided may be purchased on request. You will also have an option of an exclusive license to that Affimer for R&D purposes. *(equivalent molar binding capacity to approximately 1 mg of IgG)

  • Avia Biosystems

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    AVIA Biosystems is helping Bio-Pharmaceutical companies gain critical insights about Protein Stability to advance the best molecules faster, fail challenging molecules sooner, and optimize formulation and process conditions, potentially saving millions of dollars in financial and human resources for their businesses.
    AVIA Biosystems has developed the first automated ICD (Isothermal Chemical Denaturation) Systems to the biopharmaceutical industry.  These systems provide simultaneous determination of protein stability and aggregation at temperatures meaningful to the processing and long-term storage of therapeutic proteins.  ICD systems are utilized at multiple stages in the biologics development process including protein construct stability rank-ordering, process conditions optimization, pre-formulations screening and formulations optimization.  In early stage development, ICD data contributes significantly to the developability assessment of new biologics.  In later stage development, ICD data enables quantitative, thermodynamically directed, formulations optimization.  ICD provides valuable insights and guidance about the compromises between protein conformational stability, solubility and viscosity that need to be addressed during formulations optimization.  The optimal biologic formulation is the one that provides optimal long-term stability and ICD is able to provide quantitative guidance throughout the formulation optimization process by measuring protein stability, native protein self-association and denatured protein aggregation as a function of formulation buffer and excipient conditions.

  • Blirt

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    Blirt is the leading provider of comprehensive, high quality non-GMP recombinant proteins and bio-manufacturing services in Poland. With over 6 years of experience in recombinant protein production and a team of in-house experts specializing in E. coli, yeast and mammalian expression, we have succeeded in over 200 projects done for numerous pharma and biotech clients, including long-term Big Pharma collaboration for non-GMP proteins for R&D use.

    Our services cover:

    • Protein production
    • Monoclonal & polyclonal antibody production (as part of comprehensive projects)
    • Cell Line Development
    • Recombinant IgG production
    • SPR Services
  • Chelatec

    Chelatec

    Chelatec provides customized services in the specific fields of radiolabeling and preclinical research. Our mission is to assist the pharmaceutical and biotechnology industry along the drug development process by using the radioactive tracer for Bioanalyses, PharmacoKinetics and ADME studies. We propose following services:

    Radioisotopic Labelling

    - Radio-Iodination of Biologicals (antibodies, ADC, proteins, peptides, antigens, ligands)

    - Customized radiolabeling

    - R&D in Nuclear Medicine: Radiopharmaceuticals for Diagnostic and Therapy

    In vitro Evaluation

    - Affinity constants, Inhibition constants

    - Radioimmunoassays

    - Cytotoxicity assays

    In vivo Behaviour

    - Pharmacokinetics, clearance

    - Assessment of animal models

    - Distribution (ADME) in mice or rats from various administration routes SC, IV, IP, oral, nasal

    - Whole Body Autoradiography

    The complementary services are proposed to address the need of in vivo data of drug candidates prior to the selection and drug development. A complete in-house offer based on our dedicated lab facilities (radioactivity and animal housing) to serve our clients in a cost-effective way.

     

  • Cobra Bio

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    Cobra provide a comprehensive biologics and pharmaceuticals service offering, with multi-functional and experienced project teams nurturing customers products through to clinical and commercial manufacture within three GMP approved facilities. Expertise: Cobra are a Contract Manufacturing Organisation (CMO) supporting the global life sciences industry in the development and manufacture of monoclonal antibodies (mAb), recombinant proteins, DNA, viruses, phage and cell line derived products and pharmaceuticals for clinical trials and commercial supply. Experience: Over 15 years of track record in producing biologics and pharmaceuticals for use in pre-clinical to Phase III clinical trials and commercial supply has given our people a unique knowledge base as both manufacturer and also as service providers for the global life sciences market.We offer a broad range of integrated and stand-alone development services, stretching from cell line development to the supply of investigational medicinal product for clinical trials and commercial market supply. Excellence: Every program complies with cGMP standards worldwide and is conceived with an unmatched quality derived from the know-how of Cobra’s highly qualified, flexible and dedicated people.

  • DNA 2.0

    DNA2.0 is the leading bioengineering solutions provider. Founded in 2003, DNA2.0 provides an integrated pipeline of solutions for the research community, including gene design, optimization, synthesis and cloning, as well as platforms for protein and strain engineering. It is the fastest provider of synthetic genes—based in the US with a global customer base encompassing academia, government and the pharmaceutical, chemical, agricultural and biotechnology industries. DNA2.0 is by far the most published synthetic gene vendor, providing expert support to and collaboration with scientists. DNA2.0 explores novel applications for synthetic genes and is exploiting the synergy between highly efficient gene design and synthesis processes and new protein optimization technologies. DNA2.0’s tools and solutions are fueling the transformation of biology from a discovery science to an engineering discipline. The company is privately held and is headquartered in Menlo Park, California.

  • Eurogentec

    Eurogentec, part of Kaneka Corporation, is a leading global supplier of innovative reagents, kits, specialty products and custom services. Through its three inter-related business units (BU), the company provides high quality products to scientists involved in the life science, biotechnology, diagnostic and pharmaceutical markets. Eurogentec is fully ISO 9001, ISO 13485 certified, cGMP accredited by the Belgian Ministry of Health and approved by the US FDA for the commercial manufacturing of a biologic for the US market. The Life Science Research BU is specialized in innovative solutions in Genomics and Proteomics. Expert in small and large-scale synthesis, Eurogentec proposes a wide range of reagents, kits and consumables for Life Science applications such as Custom Oligonucleotides, high performance PCR/qPCR Kits & Reagents (including high pure Diamond Taq® DNA Polymerases), catalogue dyes, peptides & antibodies. Eurogentec is also specialist in the design and synthesis of custom peptides and production of custom antibodies (including a 28-day Speedy protocol). The Diagnostic Services BU provides technical and project support for contract manufacturing of GMP oligonucleotides and Taq DNA polymerases for use in Molecular Diagnostic applications.  Eurogentec also proposes the production of custom pre-dispensed assays in a GMP environment. As a certified ISO 13485 and GMP compliant manufacturer, our manufacturing processes take place in classified clean rooms with controlled processes and full traceability. Our production facilities in Belgium enable high quality materials for the in vitro Diagnostic community. The GMP BioManufacturing BU is a US FDA inspected full-service Contract Manufacturing Organization (CMO) that offers expertise in technology transfer, process development, scale-up and cGMP manufacturing of proteins, protein conjugates, plasmid DNA and bacterial vaccines for pre-clinical, clinical and commercial uses. Experts in microbial production (E. coli, P. pastoris, etc), Eurogentec offers various development strategies based on protein refolding, periplasmic expression, and protein expression by secretion. As a one-stop shop, Eurogentec provides a complete gene to injectable service offering. Eurogentec has been GMP since 1994 and has developed over 85 different GMP biopharmaceuticals.

  • Eurotechnologies

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    Eurotechnologies is centrally located in the UK on the Wirral in Cheshire and the appointed exclusive distributor of Biovest International’ AcuSyst™ products in Europe. Delivering cell culture instruments, consumables, instrument servicing and dedicated customer support to the European biotechnology market, we offer a total package of supply and support covering a comprehensive range of cell culture systems. Core competencies are technical support, technical service and training. Focusing on meeting customers’ requirements in a timely manner, we offer a "Technical Excellence" benchmark to fully enhance and complement our customers’ needs and expectations. The staff and directors at Eurotechnologies have many years of experience with hollow fibre bioreactors and have supported hollow fibre technology since 1987. Forming Eurotechnologies in 2004 and then expanding to be the exclusive European Acusyst™ distributor, we have been able to offer services and continued support to major pharmaceutical companies, both therapeutic and diagnostic, in countries as diverse as South Africa, India, and sites across the Middle East.

  • Evotec

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    Evotec is a drug discovery solutions company providing drug discovery expertise and capabilities to pharmaceutical and biotechnology companies as well as to academic institutions. Drug discovery solutions are provided in form of fee-for-service work, integrated drug discovery alliances, development partnerships, licensing of innovative drug candidates and consulting arrangements. The Company operates worldwide and has leading scientific experts, state-of-the-art technologies as well as key therapeutic expertise in the areas of neuroscience, pain, metabolic diseases, oncology, inflammation and infectious diseases. By leveraging this expertise, Evotec intends to develop best-in-class and first-in-class differentiated therapeutics on its systematic, unbiased and comprehensive infrastructure. Evotec has long-term discovery alliances with partners including Bayer, Boehringer Ingelheim, CHDI, Genentech, Janssen Pharmaceuticals, MedImmune/AstraZeneca, Roche and UCB. In addition, the Company has existing development partnerships and product candidates both in clinical and pre-clinical development. These include partnerships with Boehringer Ingelheim and MedImmune in the field of diabetes, with Janssen Pharmaceuticals in the field of depression and with Roche in the field of Alzheimer’s disease. Evotec is built on integrated drug discovery know-how of 20 years and is a leading player in the drug discovery field. The Company’s headquarters are located in Hamburg, Germany. Additional major operating sites exist in Abingdon and Manchester, UK; Göttingen and Munich, Germany as well as South San Francisco, Princeton and Branford, USA. Evotec has more than 600 employees worldwide.

  • Fujifilm Diosynth Biotechnologies

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    FUJIFILM Diosynth Biotechnologies is an industry leading Biologics Contract Development and Manufacturing Organisation with locations in Billingham, United Kingdom and Research Triangle Park, North Carolina, USA.  Between them the two sites have received successful FDA inspections for the manufacture of a total of five commercial products across a range of microbial and cell culture based biologics.
    Long recognised as a world leader in the process development and manufacture of microbial-derived biologics, the company has significantly expanded its mammalian cell culture capabilities in the last two years.  A new mammalian cell culture manufacturing facility was commissioned in October 2013 at the Billingham, UK site; this has been designed primarily to utilise single-use technologies, with the initial installation of a 1000L single-use bioreactor, with a 2000L bioreactor installed in late 2014 to meet customer demand.  This facility complements 1000L and 2000L single-use bioreactors at the company’s RTP plant.  

  • Gyros

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    Gyros AB is the world leader in utilization of microfluidic technologies to miniaturize and automate immunoassays. Gyros’ immunoassay platforms bring increased productivity and efficiency to the development of biotherapeutics and vaccines. Major biopharmaceutical companies and their service providers utilize Gyros’ platforms to boost time-critical workflows and to meet increasingly stringent regulatory demands on testing. Spanning the entire spectrum of immunoassays, the platforms cut the time to result significantly. Faster assay development times, and unattended running of assays at nanoliter-scale, save labor and sample. The ease of assay transfer between sites and from development to regulated environments is unsurpassed in the industry. The company has around 70 employees based at its headquarters in Uppsala, Sweden and at regional sales and support offices in the USA and Europe, plus a growing network of distributors.

  • Ibis Technologies

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    IBIS Technologies is a privately owned company developing innovative label-free analytical systems for profiling biomolecular interactions using Surface Plasmon Resonance imaging (SPRi) technology. SPR is the recognised golden standard for obtaining accurate kinetic data. Because of its multiplex format and the back-and-forth flow technology for ligand deposition and sample injection, the IBIS MX96 analyses 96 (bio)molecular interactions simultaneously using only 100 ul of sample volume. Saving your research department time, labour, sensors and sample. By injecting 96 analytes in series using the MX96's autosampler, almost 10,000 sensorgrams are obtained in an overnight run. Months of work can be saved and the time consuming screening for epitope discovery can be speed up dramatically. Especially for the applications as epitope discovery, affinity ranking and cell interaction studies, the IBIS MX96 has proven its success at large pharmaceutical companies, biotech companies and universities.

  • Isogenica

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    Isogenica discovers antibodies and other biologics using a suite of state-of-the-art complementary technologies. We are world leaders in the fabrication of novel libraries using Colibra™ – our proprietary pioneering codon-to-codon enzyme-based library synthesis method. Using Colibra™ and cutting edge library designs, Isogenica are producing the best-in-class Next-Generation of Antibody Libraries (scFv, VHH and Fab) that can be utilized to rapidly select and develop hits against difficult targets. Our libraries have been designed to maximize functional diversity and generate products that are defined by clear performance metrics for affinity, bio-manufacturing and ultimately clinical use. Our libraries are designed in partnership with US based DistributedBio – world experts in computational immunology. In addition to our antibody discovery capabilities, we also have extensive experience in the discovery and development of peptides and protein scaffolds. Isogenica leverages its suite of technologies to establish a wide range of partnerships with pharmaceutical and biotechnology companies.

  • Malvern

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    Malvern’s technology and expertise supports pharmaceutical and biopharmaceutical research and testing, for better characterization and control of proteins and other biopolymers in solution, as well as the analysis of biological carriers used in drug delivery. The data that Malvern’s instruments provide helps accelerate research and product development, and enhances and safeguards product quality. Protein charge, size, mass, molecular weight and polydispersity are key measurement parameters. Malvern’s Zetasizer instruments use dynamic and static light scattering to measure size, molecular weight and protein charge; Viscotek size exclusion chromatography (SEC) systems and detectors enable the rapid, reliable characterization of  molecular weight, mass and structure; Sysmex FPIA-3000 dynamic imaging allows size and shape characterization of protein aggregates and subvisible particles; the Archimedes system uses resonant mass measurement to provide particle counting capability, as well as aggregate mass determination; and the Viscosizer 200 draws on capillary electrophoresis technology to enable measurement of particle size and concentration as well as formulation viscosity. Spanning a wide range of applications these systems are used to help identify and develop better drug candidates, improve productivity in biomanufacturing and understand protein function. This may include the characterization of antibodies and understanding protein changes in disease; measuring protein stability for formulation development; optimizing the separation of biological materials in bioprocessing; and assessing the biocomparability of protein therapeutics. www.malvern.com

  • PRA Health Sciences

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    PRA Health Sciences delivers innovative drug development solutions that improve patients’ lives. Our people are passionate about clinical research, working tirelessly to provide quality results for clients. We offer exceptional experience across all phases, therapeutic areas and a broad spectrum of solutions, ranging from full-service clinical development to our pioneering Embedded model. With 10,000+ employees covering 80+ countries, we bolster an impressive global presence with keen local insights. Our project teams harness their understanding of local regulations, standards of care and cultural customs to effectively align our approaches with each study’s unique goals. At PRA, we love what do, because we are making a difference in the lives of patients and their family members worldwide. Over the years, we have contributed to the development of numerous drugs now available to countless patients. From our scientific and medical experts to therapeutically aligned project managers and monitors, we provide the commitment and expertise needed for today’s complex studies.

  • Reichert Technologies

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    Reichert's surface plasmon resonance (SPR) systems provide the diverse interests of academia and industry with the most cost-effective, sensitive and flexible platforms in today's marketplace. These systems supply a comprehensive characterization of molecular interactions that are important to researchers in numerous scientific disciplines. These interactions include but are not limited to protein-protein, protein-peptide, protein-nucleic acid and protein-small molecule. Each system generates information-rich data to determine such key parameters as binding association/dissociation rate constants (kinetics), equilibrium (affinity) constants, thermodynamics and concentration.  Reichert offers robust, reliable and powerful SPR biosensors for label-free, real-time bio-molecular interaction analysis. In addition to our two-channel systems – the SR7000DC and SR7500DC, on display is our new 4-channel surface plasmon resonance instrument, the Reichert4SPR. Investigate Protein-Protein, Protein-Antibody and other biomolecular interactions label-free and in real time with the Reichert4SPR. Visit www.reichertspr.com to learn more.

     

  • Roche

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    Roche Custom Biotech provides products and services to the Diagnostic Industry, Life Science Industry and PharmBiotech Industry. Enzymes, substrates and reagent components are key products for manufacturers of clinical chemistry, immunological and molecular diagnostic kits. Enzymes for cleavage and glycoengineering of proteins, PCR-based kits for microbiolgical quality control are used for biopharmaceutical production. Cedex Bio and Cedex Bio HT Analyzers are provided for the monitoring of substrates and metabolites in bioprocesses. The Cedex HiRes Analyzer allows the monitoring of mammalian cell growth and viability.

  • Schrodinger

    Schrödinger makes significant investments in R&D, which has led to major advances in the field of computational chemistry. Working closely with its scientific advisory board – a distinguished group of leading academic and industrial scientists who collectively have thousands of publications, many of which represent groundbreaking advancess – Schrödinger has achieved breakthroughs in quantum chemistry, molecular modeling, force fields, molecular dynamics cs, protein structure determination, scoring, and vd virtual screening. Schrödinger's methods development and applications papers have thousands of citations and are often among the most-cited scientific publications. Schrödinger's science is continually validated internally and by its users worldwide. The company's full product offerings range from general molecular modeling programs to a comprehensive suite of drug design software, as well as a state-of-the-art suite for materials research. Schrödinger is developing enterprise level software that can be deployed throughout an entire research organization, and the company is committed to providing integrated software so solutions and services that truly meet its customers’ needs. Schrödinger wants to empower researchers around the world to achieve their goals of improving human health and quality of life through advanced computational techniques that transform the way chemists design compounds and materials. s. By building and deploying breakthrough scientific software solutions and forming collaborations and partnerships, Schrödinger helps scientists accelerate their research and development activities, reduce costs, and make novel discoveries that might otherwise not be possible. Founded in 1990, Schrödinger has operations in several locations within the United States as well as in Europe, India, a, and Japan.

  • Sigma-Aldrich

  • Thermo Fisher Scientific

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    Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and approximately 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermofisher.com.

  • TSI

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    As an international leader in measurement technology for over 50 years, TSI Incorporated (www.tsi.com) designs and manufactures precision instruments which are recognized by researchers worldwide.
    TSI´s MacroIMS Macroion Mobility Spectrometer is a powerful tool for rapid, high resolution size and mass analysis of large proteins and their agglomerates. Developed out of core technology for nanoparticle analysis, the MacroIMS system offers utility in a variety of biochemical applications.
    For more information and to talk to an expert, visit Stand # 7

  • TTP Labtech

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    Multiplexing antibody discovery assays means that multiple targets can be investigated in the same well, making the cost of screening cheaper as well as giving more stringent results.
    TTP Labtech’s mirrorball® combines the power of flow and imaging by simultaneously capturing multiple fluorescence channels of data from microplate wells. It removes the need for wash steps and allows multiple targets to be studied. mirrorball® can run screening assays in high density 96-, 384- and 1536-well plates, streamlining screening workflows considerably. It also allows cells and beads to be colour-coded to identify binding for different targets in the same well with different cells or beads.
    Researchers have used mirrorball® to identify antibody cross-reactivity and selectivity but – significantly – in the same sample and without the loss of throughput.

  • Xpress Biologics

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    Xpress Biologics is a biotech company proposing contract services for the production of recombinant proteins, antibody fragments and plasmid DNA for preclinical applications specific to the therapeutic and diagnostic markets (human & veterinary).
    Its mission is to enable the transition of the projects from R&D to clinical manufacturing.
    The production scale (from 100 mg up to several tens of grams) and the quality of the biologics (R&D and GLP grade material) proposed by Xpress Biologics are adapted for in vitro and in vivo pre-clinical validation of the biologics (proof-of-concept, early safety, potency, efficacy…).
    The production processes are all developed in microbial expression systems, E. coli (soluble cytoplasmic, inclusion bodies and periplasmic productions) and P. pastoris (secreted protein) mainly.
    Moreover, Xpress Biologics processes are free of charge in terms of license or royalty fees and take into account the industrial (scale-up) and regulatory requirements, including the development of the quality controls, which greatly facilitates the transfer of the project to CMOs (Contract Manufacturing Organizations) for the production of GMP grade material.
    Xpress Biologics acts as One-Stop-Shop and can, through project management with defined subcontractors, take in charge additional services as the production of GMP grade material, the organization of pre-clinical and clinical studies.

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