Proteins & Antibodies Sponsors 2015

  • Absolute Antibody

    Absolute Antibody is a CRO offering fully customised services for the sequencing, engineering and manufacture of antibodies. Located across two sites in the UK, Absolute Antibody is a recently established company run by a leadership team with a wealth of experience in the development and manufacture of therapeutic antibodies. We focus on making the production of milligram to gram quantities of antibody quicker and more cost effective for early to mid-stage therapeutic projects through the use of proprietary vectors (pUV™), a high-yielding transient mammalian cell line (ABS293™) and a universal purification platform. For early stage projects we offer a variant screening service for cloning and production of microgram to milligram quantities of as many as 96 antibodies in parallel. For later stage projects we offer rapid manufacture of almost any antibody format, such as IgG, Fab and Fab2, up to gram quantities with high purity and low endotoxin suitable for all in vitro and in vivo uses.

  • Agilent Technologies

    Agilent is a leader in the Pharma, life sciences, diagnostics and applied markets. The company provides laboratories worldwide with instruments, services, consumables, applications and expertise, enabling customers to gain the insights they seek. Agilent has one of the broadest solutions portfolios of any company serving the pharmaceutical industry. Our solutions provide precise answers for every segment of the pharmaceutical industry, from disease research and drug discovery to drug development, manufacturing and quality control. The start To finish solution set means customers can get products to market faster. Customers trust us to help them test the purity of their therapeutics. Agilent also ensures that their instruments and processes conform to the highest compliance regulations.

  • Aldevron

    Aldevron provides custom plasmid DNA manufacturing to support many gene and cell therapy applications. With our experience and scientific expertise, we have developed screening strategies to optimize yield and stability of even the most challenging vector plasmids. We also provide consistency at all levels, with a deliberate pathway from research to clinical requirements.  Visit with our team to learn about our additional services including, mRNA, protein production, gene synthesis and antibody development. Aldevron's mission is to advance science, and we have solutions that are designed for you.

  • Avia Biosystems

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    AVIA Biosystems is helping Bio-Pharmaceutical companies gain critical insights about Protein Stability to advance the best molecules faster, fail challenging molecules sooner, and optimize formulation and process conditions, potentially saving millions of dollars in financial and human resources for their businesses.
    AVIA Biosystems has developed the first automated ICD (Isothermal Chemical Denaturation) Systems to the biopharmaceutical industry.  These systems provide simultaneous determination of protein stability and aggregation at temperatures meaningful to the processing and long-term storage of therapeutic proteins.  ICD systems are utilized at multiple stages in the biologics development process including protein construct stability rank-ordering, process conditions optimization, pre-formulations screening and formulations optimization.  In early stage development, ICD data contributes significantly to the developability assessment of new biologics.  In later stage development, ICD data enables quantitative, thermodynamically directed, formulations optimization.  ICD provides valuable insights and guidance about the compromises between protein conformational stability, solubility and viscosity that need to be addressed during formulations optimization.  The optimal biologic formulation is the one that provides optimal long-term stability and ICD is able to provide quantitative guidance throughout the formulation optimization process by measuring protein stability, native protein self-association and denatured protein aggregation as a function of formulation buffer and excipient conditions.

  • Blirt

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    Blirt is the leading provider of comprehensive, high quality non-GMP recombinant proteins and bio-manufacturing services in Poland. With over 6 years of experience in recombinant protein production and a team of in-house experts specializing in E. coli, yeast and mammalian expression, we have succeeded in over 200 projects done for numerous pharma and biotech clients, including long-term Big Pharma collaboration for non-GMP proteins for R&D use.

    Our services cover:

    • Protein production
    • Monoclonal & polyclonal antibody production (as part of comprehensive projects)
    • Cell Line Development
    • Recombinant IgG production
    • SPR Services
  • Chelatec

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  • Cobra Bio

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    Cobra provide a comprehensive biologics and pharmaceuticals service offering, with multi-functional and experienced project teams nurturing customers products through to clinical and commercial manufacture within three GMP approved facilities. Expertise: Cobra are a Contract Manufacturing Organisation (CMO) supporting the global life sciences industry in the development and manufacture of monoclonal antibodies (mAb), recombinant proteins, DNA, viruses, phage and cell line derived products and pharmaceuticals for clinical trials and commercial supply. Experience: Over 15 years of track record in producing biologics and pharmaceuticals for use in pre-clinical to Phase III clinical trials and commercial supply has given our people a unique knowledge base as both manufacturer and also as service providers for the global life sciences market.We offer a broad range of integrated and stand-alone development services, stretching from cell line development to the supply of investigational medicinal product for clinical trials and commercial market supply. Excellence: Every program complies with cGMP standards worldwide and is conceived with an unmatched quality derived from the know-how of Cobra’s highly qualified, flexible and dedicated people.

  • DNA 2.0

    DNA2.0 is the leading bioengineering solutions provider. Founded in 2003, DNA2.0 provides an integrated pipeline of solutions for the research community, including gene design, optimization, synthesis and cloning, as well as platforms for protein and strain engineering. It is the fastest provider of synthetic genes—based in the US with a global customer base encompassing academia, government and the pharmaceutical, chemical, agricultural and biotechnology industries. DNA2.0 is by far the most published synthetic gene vendor, providing expert support to and collaboration with scientists. DNA2.0 explores novel applications for synthetic genes and is exploiting the synergy between highly efficient gene design and synthesis processes and new protein optimization technologies. DNA2.0’s tools and solutions are fueling the transformation of biology from a discovery science to an engineering discipline. The company is privately held and is headquartered in Menlo Park, California.

  • Euro Technologies

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    Eurotechnologies is centrally located in the UK on the Wirral in Cheshire and the appointed exclusive distributor of Biovest International’ AcuSyst™ products in Europe. Delivering cell culture instruments, consumables, instrument servicing and dedicated customer support to the European biotechnology market, we offer a total package of supply and support covering a comprehensive range of cell culture systems. Core competencies are technical support, technical service and training. Focusing on meeting customers’ requirements in a timely manner, we offer a "Technical Excellence" benchmark to fully enhance and complement our customers’ needs and expectations. The staff and directors at Eurotechnologies have many years of experience with hollow fibre bioreactors and have supported hollow fibre technology since 1987. Forming Eurotechnologies in 2004 and then expanding to be the exclusive European Acusyst™ distributor, we have been able to offer services and continued support to major pharmaceutical companies, both therapeutic and diagnostic, in countries as diverse as South Africa, India, and sites across the Middle East.

  • Eurogentec

  • Fujifilm Diosynth Biotechnologies

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    FUJIFILM Diosynth Biotechnologies is an industry leading Biologics Contract Development and Manufacturing Organisation with locations in Billingham, United Kingdom and Research Triangle Park, North Carolina, USA.  Between them the two sites have received successful FDA inspections for the manufacture of a total of five commercial products across a range of microbial and cell culture based biologics.
    Long recognised as a world leader in the process development and manufacture of microbial-derived biologics, the company has significantly expanded its mammalian cell culture capabilities in the last two years.  A new mammalian cell culture manufacturing facility was commissioned in October 2013 at the Billingham, UK site; this has been designed primarily to utilise single-use technologies, with the initial installation of a 1000L single-use bioreactor, with a 2000L bioreactor installed in late 2014 to meet customer demand.  This facility complements 1000L and 2000L single-use bioreactors at the company’s RTP plant.  

  • Gyros

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  • Ibis Technologies

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  • Isogenica

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    Isogenica discovers antibodies and other biologics using a suite of state-of-the-art complementary technologies. We are world leaders in the fabrication of novel libraries using Colibra™ – our proprietary pioneering codon-to-codon enzyme-based library synthesis method. Using Colibra™ and cutting edge library designs, Isogenica are producing the best-in-class Next-Generation of Antibody Libraries (scFv, VHH and Fab) that can be utilized to rapidly select and develop hits against difficult targets. Our libraries have been designed to maximize functional diversity and generate products that are defined by clear performance metrics for affinity, bio-manufacturing and ultimately clinical use. Our libraries are designed in partnership with US based DistributedBio – world experts in computational immunology. In addition to our antibody discovery capabilities, we also have extensive experience in the discovery and development of peptides and protein scaffolds. Isogenica leverages its suite of technologies to establish a wide range of partnerships with pharmaceutical and biotechnology companies.

  • Malvern

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  • Roche

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  • Schrodinger

  • Sigma-Aldrich

  • Thermo Fisher Scientific

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  • TSI

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    As an international leader in measurement technology for over 50 years, TSI Incorporated (www.tsi.com) designs and manufactures precision instruments which are recognized by researchers worldwide.
    TSI´s MacroIMS Macroion Mobility Spectrometer is a powerful tool for rapid, high resolution size and mass analysis of large proteins and their agglomerates. Developed out of core technology for nanoparticle analysis, the MacroIMS system offers utility in a variety of biochemical applications.
    For more information and to talk to an expert, visit Stand # 7

  • TTP Labtech

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    Multiplexing antibody discovery assays means that multiple targets can be investigated in the same well, making the cost of screening cheaper as well as giving more stringent results.
    TTP Labtech’s mirrorball® combines the power of flow and imaging by simultaneously capturing multiple fluorescence channels of data from microplate wells. It removes the need for wash steps and allows multiple targets to be studied. mirrorball® can run screening assays in high density 96-, 384- and 1536-well plates, streamlining screening workflows considerably. It also allows cells and beads to be colour-coded to identify binding for different targets in the same well with different cells or beads.
    Researchers have used mirrorball® to identify antibody cross-reactivity and selectivity but – significantly – in the same sample and without the loss of throughput.

  • Xpress Biologics

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    Xpress Biologics is a biotech company proposing contract services for the production of recombinant proteins, antibody fragments and plasmid DNA for preclinical applications specific to the therapeutic and diagnostic markets (human & veterinary).
    Its mission is to enable the transition of the projects from R&D to clinical manufacturing.
    The production scale (from 100 mg up to several tens of grams) and the quality of the biologics (R&D and GLP grade material) proposed by Xpress Biologics are adapted for in vitro and in vivo pre-clinical validation of the biologics (proof-of-concept, early safety, potency, efficacy…).
    The production processes are all developed in microbial expression systems, E. coli (soluble cytoplasmic, inclusion bodies and periplasmic productions) and P. pastoris (secreted protein) mainly.
    Moreover, Xpress Biologics processes are free of charge in terms of license or royalty fees and take into account the industrial (scale-up) and regulatory requirements, including the development of the quality controls, which greatly facilitates the transfer of the project to CMOs (Contract Manufacturing Organizations) for the production of GMP grade material.
    Xpress Biologics acts as One-Stop-Shop and can, through project management with defined subcontractors, take in charge additional services as the production of GMP grade material, the organization of pre-clinical and clinical studies.

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